MAGIC cohorts

Cohorts who have contributed to MAGIC projects are described below. This page is continuously being updated to include information on new cohorts participating to MAGIC ongoing projects.

The Avon Longitudinal Study of Parents and Children (ALSPAC)

ALSPAC is a prospective study, which recruited pregnant women with expected delivery dates between April 1991 and December 1992 from Bristol UK. The study methods are described elsewhere and on the study website ALSPAC webpages Detailed information was obtained from the mother (about herself and her child) and her partner by means of questionnaires. From age 7 years onward, the whole cohort of children was invited to attend regular research clinics where anthropometric measures were taken as described previously. DNA was collected and extracted as described previously.

Amish Studies

The Old Order Amish (OOA) population of Lancaster County, PA immigrated to the United States from Western Europe in the late 1700's. There are now approximately 30,000 OOA individuals in the Lancaster area, nearly all of whom can trace their ancestry back 12-14 generations to a small number of founder families. The Amish have large sibships, a high degree of consanguinity, well-documented genealogies, and a predominantly rural lifestyle. These features make this population attractive for genetic analysis. For more, please visit the AMISH website

Atherosclerosis Risk in Communities Study (ARIC)

The ARIC Study, sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date. For more, please visit the ARIC website

Baltimore Longitudinal Study of Aging (BLSA)

The National Institute on Aging (NIA) conducts research to learn about the changes that take place as we age. One goal of NIA research is to help us understand medical problems that are common in older people. The NIA supports the Baltimore Longitudinal Study of Aging (BLSA), America's longest-running scientific study of human aging, begun in 1958. BLSA scientists are learning what happens as people age and how to sort out changes due to aging from those due to disease or other causes. More than 1,400 men and women are study volunteers. They range in age from their 20s to their 90s. For more, please visit the BLSA website

The Botnia Study

The Botnia study was initiated in 1990 on the western coast of Finland in the Gulf of Bothnia with the aim to: (1) characterize the early metabolic defects in individuals at risk of developing type 2 diabetes, (2) identify genetic variants predisposing to type 2 diabetes, (3) study how the identified genetic markers and biomarkers can predict the development of type 2 diabetes and progression of the disease, and (4) identify means to prevent the development of type 2 diabetes. The Botnia Study, which is probably the largest family study on T2DM in the world, includes about 10,000 subjects from 1400 families in Finland and Southern Sweden. Of them, 3225 already have diabetes, the others are either relatives at an increased risk or population-based control subjects. Mortality data during the follow-up of 13 years are available. The non-diabetic subjects are prospectively followed every 3 years. For more, please visit the Botnia Study website

British Women's Heart and Health Study (BWHHS)

No further Information on this study, at this time.

The Busselton Health Study

The Busselton Health Studies group manages and maintains the BHS database. Maintenance includes annual mortality follow-up, periodic hospital morbidity updates, tracing of previous survey participants and improving information on family relationships among survey participants. The group, independently and in collaboration with other Busselton Health Studies researchers, uses the accumulated data to conduct research into: epidemiology of cardiovascular diseases; epidemiology of respiratory diseases; mortality and hospital admission rates; familial aggregation of chronic diseases and disease risk factors For more, please visit the BHS Study website

Caerphilly Prospective Study

No further Information on this study, at this time.

Cardiovascular Health Study

The Cardiovascular Health Study is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older. Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. An additional examination took place in 2005-6. Measurements included traditional risk factors such as blood pressure and lipids as well as measures of subclinical disease, including echocardiography of the heart, carotid ultrasound, and cranial magnetic-resonance imaging. At six month intervals between clinic visits, and once clinic visits ended, participants were contacted by phone to ascertain hospitalizations and health status. The main outcomes are coronary heart disease, angina, heart failure, stroke, transient ischemic attack, claudication, and mortality. Participants continue to be followed for these events. As of June 2011, more than 750 research papers from CHS have been published and more than 120 ancillary studies are ongoing or complete. For more, please visit the CHS website

The CoLaus Study

The Cohorte Lausannoise (CoLaus) study is a population-based study aimed at assessing the prevalence and molecular determinants of cardiovascular risk factors in the population of Lausanne, Switzerland. Participants in the study (n=6188) were randomly selected from the population register of Lausanne in 2003 (N=56,694, aged 35-75 years). All individuals were of European origin, defined as having both parents and grandparents born in a defined list of European countries. The initial cross sectional study took place between 2003 and 2006 and since 2009 we started the first follow-up of the entire cohort.For more information, please visit the CoLaus study website.

The Croatian Study (CROAS)

The Croatian study (CROAS; Croatia) is a family-based study of residents of small villages in a Dalmatian island. The village populations of this and neighbouring islands in Croatia represent a well-characterised meta-population of genetic isolates. The CROAS study investigated approximately 1000 unselected Croatian residents, aged 18¯93 years, from villages on the Dalmatian island. As above, each participant was examined for a large number of disease-related traits

Diabetes Genetics Initiative

The Diabetes Genetics Initiative combines the resources and expertise of the Novartis Institutes for BioMedical Research, the Broad Institute of MIT and Harvard, and Lund University to identify the genetic determinants of type 2 diabetes. This unique collaboration aims to collect and analyze samples from type 2 diabetic patients, performing whole genome scans to provide a comprehensive view of the DNA sequence variants associated with the disease. This partnership has been forged with the explicit goal of making this vast amount of crucial data available to researchers globally and free of cost, which should lead to a greater understanding of disease biology and speed the development of more effective therapies. For more, please see Science. 2007 Jun 1;316(5829):1331-6

DIAbetes GENetic Study (DIAGEN)

The DIAbetes GENetic study is a single-center prospective study of the genetics of diabetes based at the Carl Gustav Carus Medical School at the Dresden University of Technology that began in 1997 and seeks to understand the genetic causes of diabetes development. In DIAGEN, DNA samples of very well phenotyped subjects in different pathopysiological stages of diabetes mellitus development are collected to study the genetic causes of diabetes development. To date, we have studied more that 6000 subjects of different metabolic disease phenotypes deriving from multiple ethnic groups, mostly from the German state of Saxony. All individuals have extensive phenotyping including clinical examination (anthropometrics, blood pressure, clinical chemistry, physical examination, ECG), a 75g oral glucose tolerance test following an overnight period of fasting (10 hours minimum) with measurements of plasma glucose, insulin, proinsulin, C-peptide, and free fatty acids (NEFA) at fasting and at 30, 60, 90 and 120 minutes after glucose challenge, together with lipids, adipokines and inflammatory parameters measurements at fasting. The presented study was supported by the Commission of the European Communities, Directorate C - Public Health and Risk Assessment, Health & Consumer Protection, Grant Agreement number - 2004310 and by the Dresden University of Technology Funding Grant, Med Drive.

deCODE Study

The DECODE cohort included pooled data from European epidemiological studies on diabetes and impairment of glucose regulation in which oral glucose tolerance tests were performed. A total of 4,715 men and 5,554 women 30 to 89 years of age were followed for a period ranging from 7 to 16 years. For more, please visit the deCODE study website

DEsIR Study

No further Information on this study, at this time.

The Ely Study

The Ely study The Ely study was commenced in 1990 as a prospective population-based cohort study of the aetiology and pathogenesis of Type 2 Diabetes and related metabolic disorders with the aims of (i) Understanding the pathogenesis of Type 2 diabetes in a Caucasian population through longitudinal examination of people free of diabetes at baseline; (ii) Determining early markers of future risk of progression of glucose intolerance and providing the means to identify populations at high risk of diabetes; and (iii) Quantifying and specifying the role of key exposures in adult life, particularly diet and physical activity. For more, please visit the Ely Study website

The Erasmus Rucphen Family Study

The Erasmus Rucphen Family study (ERF) consists of some 3000 genealogically documented individuals from a Dutch genetic isolate. Data on waist circumference, blood pressure, HDL-C, triglycerides and fasting plasma glucose levels are available.

Exeter Family Study of Childhood Health

The Exeter Family Study of Childhood Health was a prospective study on 1000 families from Exeter (father, mother and offspring) recruited during the normal pregnancy of the mother. Fasting blood samples were taken on the mother and father when the mother was 28 weeks pregnant. Fasting sampling was repeated in approximately 600 mothers when no longer pregnant. DNA is available from both parents and the child (taken from Cord blood). Full anthropometry is available on all subjects with the children being measured at birth, 3 months, 12 months and 24 months. Biochemistry including insulin and glucose measurement is available on parents and cord samples. Additional biochemical analysis may be possible on stored samples. For more information on phenotypes collected see Knight B, Shields BM, Hattersley AT. The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology. Paediatr Perinat Epidemiol. 2006 Mar;20(2):172-9 or visit the EFSOCH website

The Fenland Study

This is a population-based study into lifestyle and health by the MRC Epidemiology Unit. The study investigates the influence of diet, lifestyle and genetic factors and their interaction on the development of diabetes and obesity, using a wide range of detailed anthropometric, biological and clinical measurements including DEXA and ultrasound.

Nearly 8,000 participants have now been recruited to the Fenland Study, which we aim to increase to 10,000 over the next 2 years. These people are from the general population in the East Cambridgeshire and Fenland area and were born between 1950 and 1975. For more, please visit the Fenland website Fenland website

Finland-United States Investigation of NIDDM Genetics Study (FUSION)

The goal of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to map and identify genetic variants that predispose to type 2 diabetes mellitus (T2D) or are responsible for variability in diabetes-related quantitative traits. For more, please visit the FUSION website

Framingham Heart Study (FHS)

The Framingham Heart Study began in 1948 by recruiting an Original Cohort of 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, who had not yet developed overt symptoms of cardiovascular disease or suffered a heart attack or stroke. Since that time the Study has added an Offspring Cohort in 1971, the Omni Cohort in 1994, a Third Generation Cohort in 2002, a New Offspring Spouse Cohort in 2003, and a Second Generation Omni Cohort in 2003. FHS investigates cardiovascular disease and cardiovascular disease risk factors including diabetes, glucose and insulin levels. Genetic data has been collected as well, and is available on dbGaP in the FHS SHARE Study. For more, please visit the FHS website

French Obese Adults Cohort

No further Information on this study, at this time.

Gene-Diet Attica Investigation (GENDAI)

The Gene-Diet Attica Investigation on childhood obesity (GENDAI) evaluates the contributions to and pivotal interactions of genetic, dietary and physical activity variables on children's weight. We describe the design, methodology, and present preliminary data. So far, 920 participants have been enrolled and the final projected sample is 1000 fifth- and sixth-grade students from selected elementary schools in Attica (10-14 years). In this school-based cross-sectional study, more than 400 variables describing anthropometric, dietary, clinical, genetic, sociodemographic and other lifestyle characteristics were collected from participating children and their families.

GenomEUtwin

The population cohorts used in the Genomeutwin study consist of Danish, Finnish, Italian, Dutch, English, Australian and Swedish twins and the MORGAM population cohort. The participating 8 twin cohorts form an amazing collection of over 0.6 million pairs of twins. Tens of thousands of DNA samples with informed consents for genetic studies of common diseases have already been stored from these population-based twin cohorts. Just as the twin studies, the WHO MONICA (www.ktl.fi/monica) collaboration has a long and successful history of conducting multicentre research, which makes it ideal for embarking on genetic studies of complex, multifactorial diseases. Studies targeted to cardiovascular traits are now being undertaken in MORGAM, a prospective case-cohort study. MORGAM cohorts include approximately 6000 individuals, drawn from population-based cohorts consisting of more than 80 000 participants who have donated DNA samples. These unique study samples will be analysed in four intellectual core facilities of this integrated project using accumulated expertise by partners in genetics, epidemiology and biostatistics. For more, please visit the GenomEUtwin website

The GEMS Study

Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects.

The Greek Health Randomised Aging Study (GHRAS)

The GHRAS study is aimed at investigating the interactions among socioeconomic, lifestyle, dietary, psychological, and biochemical factors determining the health status of elderly Greeks. A total of 782 elderly (>60 years of age) Greeks were randomly recruited in Athens. Standardized anthropometric, biochemical, and clinical procedures and extensive questionnaires were used to assess health parameters and lifestyle factors.

Gene-Lifestyle interactions And Complex traits Involved in Elevated disease Risk Study (GLACIER)

The GLACIER Study (Gene-Lifestyle interactions And Complex traits Involved in Elevated disease Risk Study) is a prospective, population-based cohort study comprised of 19,547 adults from the Northern Swedish county of Västerbotten, nested within the Northern Sweden Health and Disease Study. All GLACIER participants underwent detailed health and lifestyle examinations as part of the Västerbotten Intervention Programme, an ongoing population-based prospective cohort study focused on type 2 diabetes, cardiovascular disease, and common cancers. Since 1985, all residents of the county of Västerbotten have been invited to visit their primary care centre for a clinical examination within the year of their 40th, 50th, and/or 60th birthday. The protocol is standardized across study centres and conducted by trained research nurses. Baseline examinations for GLACIER participants were undertaken from 1985 through 2004. Of the 16,398 participants free from diabetes and other major chronic diseases at baseline, 4,059 had undergone a 10-year follow-up examination between January 1995 and December 2007. The follow-up examination is identical to the baseline examination with the exceptions that waist circumference was measured and modifications had been made to questionnaires on diet and physical activity. All participants gave written informed consent and The Regional Ethical Review Board in Umeå approved all aspects of the study. The study was funded by project grants from Novo Nordisk, the Swedish Heart-Lung Foundation, the Swedish Diabetes Association, Påhlssons Foundation, the Swedish Research Council, Umeå University Career Development Award, and The Heart Foundation of Northern Sweden (all grants to the GLACIER Study PI: Paul W. Franks). The GLACIER investigators are indebted to the study participants who dedicated their time and samples to these studies.

Haguenau

The Haguenau community-based cohort of young adults investigates long-term consequences of being born small for gestational age and has previously been described. Briefly, subjects born between 1971 and 1985 were identified from a population-based registry of Haguenau (France).

HEALTH 2000: Health and Functional Capacity of Finns - a national health survey

The main aim of Health 2000 is to provide an up-to-date comprehensive picture of health and functional ability in the working-aged and aged population by studying the prevalence and determinants of most important health problems and associated need for care, rehabilitation and help. A nationally representative sample of 10,000 persons has been drawn of the population aged 18 and over. Targets of the study are general health, major chronic conditions, functional ability and limitations, determinants of health, diseases, functional ability and limitations, health needs and service needs and their satisfaction. For more, please visit the Health 2000 website

The Hertfordshire Cohort

The Hertfordshire cohort study consists of 3,000 men and women born 1931-1939 and still resident in the county. Information available on these individuals includes birthweight, weight in infancy and details of exposure to infections and infant feeding during the first year of life. The study members have been followed-up at ages 60-75 years, and 10 years thereafter. Intensive phenotyping includes assessment of body build, nutrition, physical activity, body composition, bone density by DXA, lung function, osteoarthritis, grip strength, physical fraility, and anxiety/depression.For more, please visit the Hertfordshire cohort study website

The InCHIANTI Study

For more, please visit the InCHIANTI study website

The Inter99 Study

Inter99 is a population based randomised intervention study which took place at the Research Centre for Prevention and Health. The study is based on 61,301 persons in certain age groups, living in the south western part of The Capital Region of Denmark. The aim of the study was to prevent cardiovascular disease by healthy lifestyle. A random sample was invited for screenings of the risk of cardiovascular disease and repeatedly offered assistance to improve their lifestyle, while another random sample, the control group, completed questionnaires. For more, please visit the inter99 study website

Cooperative Health Research in the Region of Augsburg, Southern Germany (KORA)

KORA is a research platform based on a population-based cohort study of 18,000 adults from Southern Germany. Recruitment started in 1984/85 and was performed in 4 surveys, followed by repeated investigations in regular intervals. Phenotyping is very broad, with a focus on cardiovascular and metabolic diseases. Biosamples of most participants (whole blood, serum, plasma, DNA, urine) are available. The KORA study is located at the Helmholtz Center Munich, Germany. For more, please visit the KORA website

MesyBePo

MesyBePo is an observation study including more than 2000 individuals from Eastern Germany. Characterization of participants is focused on cardio-metabolic phenotypes. Thus, phenotyping of all individuals included oral glucose tolerance test with insulin measurements. Among other standard lab parameters, HbA1c, lipids and blood cell count was deterimend. Intima media thickness was measured in most participants. A follow-up of participants with at least 3 years follow-up period is ongoing.

METSIM

No further Information on this study, at this time.

The Microisolates in South Tyrol Study (MICROS)

The MICROS study is a population-based survey on three small, isolated villages, characterized by: old settlement; small number of founders; high endogamy rates; slow/null population expansion. During the stage-1 (2002/03) genealogical data, screening questionnaires, clinical measurements, blood and urine samples, and DNA were collected for 1175 adult volunteers. Stage-2, concerning trait diagnoses, linkage analysis and association studies, is ongoing. For more, please visit the Institute website and MICROS study publication

Nederlands Tweelingen Register (NTR)

For more, please visit the NTR website

The NHLBI Family Heart Study

The NHLBI Family Heart Study is a multi-center population-based study of genetic and non-genetic determinants of coronary heart disease (CHD), artherosclerosis, and cardiovascular risk factors. In Phase I, 2,000 randomly selected participants and 2,000 with family histories of CHD were identified among 14,592 middle-aged participants in epidemiological studies. Medical histories from these individuals, their parents and siblings were used to calculate family risk scores which compared the number of reported and validated CHD events with the number expected based on the size, sex and age of family members. A total of 661 families with the highest risk scores and early onset of CHD and 592 randomly sampled families had clinic examinations including electrocardiograms, carotid artery ultrasound scans, spirometry, measurements of body size, blood pressure, lipids, lipoproteins, hemostatic factors, insulin, glucose, and routine chemistries. For more, please visit the NHLBI Family Heart Study website

Northern Finland Birth Cohort 1966 Studies (NFBC 1966)

The study was started by professor Paula Rantakallio in the two Northern most provinces in Finland (Oulu and Lapland) already in the year 1965 when the mothers were pregnant. Data on the individuals born into this cohort was collected since the 24th gestational week as well as their mothers and, to a lesser extent, fathers. The cohort included 12055 mothers and they had 12068 deliveries (13 women delivered twice). According to the Finland's central Office of Statistics, births in the study area during 1966 totalled 12527, so study population comprised 96.3 per cent of all births during 1966 in that area. Althougher 12231 children were born into the cohort, 12058 of them live-born. The original data have been supplemented by data collected with postal questionnaries at the ages of 1, 14 and 31 years and various hospital records and national register data. For more, please visit the NFBC website

MRC National Survey of Health and Development (NSHD)

The MRC National Survey of Health and Development is the longest running longitudinal study with continuous follow-up in the world, consisting of a nationally representative sample of 5,362 men and women whose health and socioeconomic circumstances have been measured 24 times since their birth in March 1946. The NSHD is a prospective observational epidemiological study of lifetime risk factors on adult health, ageing and mortality.

During their childhood, the main aim of the NSHD was to investigate how the environment, at home and at school, affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and how these change with age. Intensive phenotyping at age 60-64 years includes bone density by DXA and forearm pQCT, vascular structure and function by echocardiogram, ECG, a nurse interview and repeat measures of lung function, grip strength and anthropometry. Now, as participants pass retirement age, the research team is developing the NSHD into a life course study of ageing. For more, please visit the NSHD website

The Orkney Complex Disease Study (ORCADES)

The Orkney Complex Disease Study (ORCADES) is a population-based study in the isolated Scottish archipelago of Orkney. Genetic diversity in this population is decreased compared to Mainland Scotland and kinship is increased, consistent with the high levels of endogamy historically. 2100 volunteers with Orcadian ancestry aged 18-100 years were recruited between 2005-2011. Fasting blood samples were collected and over 300 health-related phenotypes and environmental exposures were measured. Phenotypes include anthropometry, haemodynamics, electrophysiology, biochemistry, haematology, clotting factors, inflammatory markers, body composition, bone density, retinal vessel traits, ophthalmological traits, personality, sleep and cognitive traits, clinical end points, and data on health behaviours, environmental exposures, family history, as well as glycomic and lipidomic datasets. 6 generation pedigrees, a biobank of DNA, plasma, serum and whole blood and prospective follow up via health record linkage are also available. High density genome-wide genotypes, custom genotyping arrays, exome and whole genome sequences are available for differing numbers of participants. For more, please visit the ORCADES website

Oxford Biobank

The Oxford Biobank is a randomised population-based cohort of healthy 5,000 men and women recruited within the age range of 30 to 50 years. All participants undergo detailed examination at a screening visit (guestionnaires, biochemistry, anthropometrics). Participant characterisation includes anthropometric characterisation (including DXA scans), beyond conventional diabetes/obesity and cardiovascular conventional biochemistry, hCRP, IGF-1, IGFBP1 and fasting insulin concentrations. For more, please visit the Oxford Biobank website

Partners/Roche

Patients with diabetes mellitus and non-diabetic control subjects, with no personal history or family history of diabetes in first degree relatives and with normal (<6.1 mmol/l or 110 mg/dl) fasting glucose levels, were recruited and evaluated by the Diabetes Center, Massachusetts General Hospital and the Division of Endocrinology and Metabolism, Brigham and Women's Hospital as part of an observational study of diabetic and pre-diabetic individuals. For more, please see Ai et al Clin Chim Acta. 2009 ;406:71-4

Procardis

Procardis is a European Commission Framework 6 funded project which exploits advances in complex trait genetics and functional genomics to discover novel susceptibility genes for coronary artery disease (CAD). PROCARDIS is incorporating a definitive genome-wide association analysis and measurement of novel intermediate phenotypes to yield biomarkers for CAD risk and quantitative traits for genetic analysis. For more, please visit the PROCARDIS website

Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)

The PIVUS study started in 2001 with the primary aim to investigate the predicive power of different measurements of endothelial function and arterial compliance in a random sample of 1000 subjects aged 70 living in the community of Uppsala. As secondary aims, the study also included measurements of cardiac function and structure by ultrasound and MRI, evaluation of atherosclerosis by ultrasound and MRI, 7 day food intake recordings, detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function, as well as a number of biochemical markers. For more, please visit the PIVUS website

Relationship Between Insulin Sensitivity and Cardiovascular Risk (RISC) study

RISC is a prospective, multicenter, observational study that has enrolled 1338 patients at 19 centers across Europe. RISC subjects are for the most part middle-aged and healthy, with no pre-existing diabetes, known CVD, or hypertension. The RISC cohort is internationally unique in that insulin sensitivity has been measured in more than 1400 Individuals (in 18 participating centres) at baseline using the euglycaemic "clamp" technique. This is a clinical research tool that involves a two hour infusion of insulin and glucose and is carried out according to standard operating procedures by carefully trained personnel.

The Rotterdam Study

The Rotterdam Study is a prospective cohort study that started in 1990 in Ommoord, a suburb of Rotterdam, among 10,994 men and women aged 55 and over. The main objective of the Rotterdam Study is to investigate the prevalence and incidence of risk factors for chronic diseases in the elderly. The chronic diseases of interest are cardiovascular, neurological, locomotor and ophthalmological. The findings from the Rotterdam Study will hopefully contribute to a better prevention and treatment of chronic diseases in the elderly. For more, please visit the Rotterdam Study website

The SardiNIA Project

SardiNIA's goal is to identify gene variants (alleles) that affect the occurrence of certain traits such as obesity, depression, or high blood pressure, which may increase the risk of certain diseases in later life, such as heart disease, diabetes, and dementia. For more, please visit the SardiNIA website

The Segovia Study

No further Information on this study, at this time.

SORBS

No further Information on this study, at this time.

The STANISLAS Family Study (SFS)

The SFS is a 10´years longitudinal survey involving 1,006 volunteer bi-parental families of French origin having at least two siblings. The main but not limiting objective of the SFS is to study gene-gene and gene-environment interactions precociously influencing cardiovascular risk factors. Participants included were free of chronic disease (cardiovascular or cancer) at recruitment between September 1993 and August 1995. More than 600 demographic and laboratory data have been collected every five years and serum, plasma and DNA has been stored. For a subsample of 357 families, mRNA (PAXGENE tubes, PBMCs) and PBMCs protein extracts have been collected. The SFS samples and data are part of the Biological Resources Centre (BRC) 'Interactions Gène-Environnement en Physiopathologie CardioVasculaire' (IGE-PCV) in Nancy, France. For more information, please consult: Clin Chem Lab Med. 2008;46(6):733-47

SUVIMAX

SUVIMAX is a major French study investigating the impact of antioxidant vitamins and minerals in the prevention of coronary heart disease and cancer and has collected diet and health information and take blood samples from 13,000 volunteers; 5000 men and 8000 women.

Twins UK

The Department of Twin Research and Genetic Epidemiology (DTR), is the UK's only twin registry of 11,000 identical and non-identical twins between the ages of 16 and 85 years. The database used to study the genetic and environmental aetiology of age-related complex traits and diseases. It is one of the major departments of King's College London Division of Genetics and Molecular Medicine and is the most detailed clinical adult register in the world. For more, please visit King's College London's Department of Twin Research and Genetic Epidemiology webpages

Umeå

No further Information on this study, at this time.

Uppsala Longitudinal Study of Adult Men (ULSAM)

ULSAM is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924, in Uppsala County, Sweden. The men were investigated at the ages of 50, 60, 70, 77, 82 and 88 years. For more, please visit the ULSAM website

Whitehall II (also known as the Stress & Health Study)

The Whitehall II study was set up in 1985 by Professor Sir Michael Marmot to investigate the importance of social class for health by following a cohort of 10,308 working men and women. Looking towards the future, the study seeks to answer questions about how previous and current circumstances affect health and quality of life in an ageing cohort. For more, please visit the Whitehall II Study website

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